Ontology highlight
ABSTRACT:
SUBMITTER: Yoo HM
PROVIDER: S-EPMC4367433 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yoo Hee Min HM Park Jong Ho JH Jeon Young Joo YJ Chung Chin Ha CH
Frontiers in endocrinology 20150320
Estrogen receptor-α (ERα) is a steroid hormone-sensitive transcription factor that plays a critical role in development of breast cancer. The binding of estrogen to ERα triggers the recruitment of transcriptional co-activators as well as chromatin remodeling factors to estrogen-responsive elements (ERE) of ERα target genes. This process is tightly associated with post-translational modifications (PTMs) of ERα and its co-activators for promotion of transcriptional activation, which leads to proli ...[more]