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Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort.

ABSTRACT: Background:We performed this study to investigate the inequalities in site-specific cancer incidences among workers across different occupations in Korea. Methods:Subjects included members of the national employment insurance. Incident cancers among 8,744,603 workers were followed from 1995 to 2007. Occupational groups were classified according to the Korean Standard Occupational Classification. Age-standardized incidence rate ratios were calculated. Results:We found that men in service/sales and blue-collar occupations had elevated rates of esophageal, liver, laryngeal, and lung cancer. Among women, service/sales workers had elevated incidences of cervical cancer. Male prostate cancer, female breast, corpus uteri, and ovarian cancers, as well as male and female colorectal, kidney, and thyroid cancer showed lower incidences among workers in lower socioeconomic occupations. Conclusions:Substantial differences in cancer incidences were found depending on occupation reflecting socioeconomic position, in the Korean working population. Cancer prevention policy should focus on addressing these socioeconomic inequalities.

SUBMITTER: Lee HE

PROVIDER: S-EPMC7078566 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort.

Lee Hye-Eun HE Zaitsu Masayoshi M Kim Eun-A EA Kawachi Ichiro I

Safety and health at work 20191231 1

<h4>Background</h4>We performed this study to investigate the inequalities in site-specific cancer incidences among workers across different occupations in Korea.<h4>Methods</h4>Subjects included members of the national employment insurance. Incident cancers among 8,744,603 workers were followed from 1995 to 2007. Occupational groups were classified according to the Korean Standard Occupational Classification. Age-standardized incidence rate ratios were calculated.<h4>Results</h4>We found that m ...[more]

PMID: 32206373

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Project description:BackgroundThe rising global incidence of cancer has increased the demand for chemotherapy, which is a crucial treatment modality. Recent advancements in cancer treatment, including targeted agents and immunotherapy, have introduced complications owing to their specific mechanisms. However, comprehensive studies of the combined complications of these approaches are lacking.ObjectivesThis study aimed to comprehensively assess and analyze the overall incidence of anticancer drug-related complications in a nationwide patient cohort, utilizing a customized National Health Insurance Sharing Service database in Korea.DesignRetrospective cohort study.MethodsWe included patients who were prescribed anticancer drugs (excluding endocrine agents) and diagnosed with cancer. For the type of cancer classification, the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) was used and anticancer drugs were classified based on the Anatomical Therapeutic Chemical code. We classified cancer into 18 types based on the ICD-10 code and delineated cancer-related complications into 12 categories. Complications included hematological, gastrointestinal, infectious, cardiovascular, major bleeding, endocrine, neurotoxic, nephrotoxic, dermatological, pulmonary, musculoskeletal, and hepatotoxic effects.ResultWe included 294,544 patients diagnosed with cancer and administered anticancer drugs between 2016 and 2018, with follow-up continuing until 2021. We identified 486,929 anticancer drug-related complications, with an incidence of 1843.6 per 1000 person-years (PY). Anemia was the most common complication, with a rate of 763.7 per 1000 PY, followed by febrile neutropenia (295.7) and nausea/vomiting (246.9). Several complications peaked during the first months following the initiation of anticancer drug therapy; however, herpes, skin infection, heart failure, and peripheral neuropathy peaked at 6-12 months. Among major cancers, breast cancer had the lowest overall incidence of complications. Targeted therapies revealed lower complication rates than cytotoxic chemotherapy; however, they also required careful monitoring of rash.ConclusionThis study highlights the importance of the proactive management of anticancer drug-related complications for patient care improvement.

Dataset Information

Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort.

Publications

Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort.

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