Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz-Guillen M
PROVIDER: S-EPMC7079800 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ruiz-Guillen Marta M Gabev Evgeni E Quetglas Jose I JI Casales Erkuden E Ballesteros-Briones María Cristina MC Poutou Joanna J Aranda Alejandro A Martisova Eva E Bezunartea Jaione J Ondiviela Marina M Prieto Jesus J Hernandez-Alcoceba Ruben R Abrescia Nicola G A NG Smerdou Cristian C
Cellular and molecular life sciences : CMLS 20160427 20
Alphavirus budding is driven by interactions between nucleocapsids assembled in the cytoplasm and envelope proteins present at the plasma membrane. So far, the expression of capsid and envelope proteins in infected cells has been considered an absolute requirement for alphavirus budding and propagation. In the present study, we show that Semliki Forest virus and Sindbis virus lacking the capsid gene can propagate in mammalian and insect cells. This propagation is mediated by the release of infec ...[more]