Ontology highlight
ABSTRACT:
SUBMITTER: Scheideler OJ
PROVIDER: S-EPMC7080440 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Scheideler Olivia J OJ Yang Chun C Kozminsky Molly M Mosher Kira I KI Falcón-Banchs Roberto R Ciminelli Emma C EC Bremer Andrew W AW Chern Sabrina A SA Schaffer David V DV Sohn Lydia L LL
Science advances 20200318 12
Elucidating how the spatial organization of extrinsic signals modulates cell behavior and drives biological processes remains largely unexplored because of challenges in controlling spatial patterning of multiple microenvironmental cues in vitro. Here, we describe a high-throughput method that directs simultaneous assembly of multiple cell types and solid-phase ligands across length scales within minutes. Our method involves lithographically defining hierarchical patterns of unique DNA oligonucl ...[more]