Ontology highlight
ABSTRACT:
SUBMITTER: Klementieva O
PROVIDER: S-EPMC7080554 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Klementieva Oxana O Sandt Christophe C Martinsson Isak I Kansiz Mustafa M Gouras Gunnar K GK Borondics Ferenc F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20200207 6
Loss of memory during Alzheimer's disease (AD), a fatal neurodegenerative disorder, is associated with neuronal loss and the aggregation of amyloid proteins into neurotoxic β-sheet enriched structures. However, the mechanism of amyloid protein aggregation is still not well understood due to many challenges when studying the endogenous amyloid structures in neurons or in brain tissue. Available methods either require chemical processing of the sample or may affect the amyloid protein structure it ...[more]