Comparison of DNA and mRNA vaccines against cancer.
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ABSTRACT:
SUBMITTER: Jahanafrooz Z
PROVIDER: S-EPMC7080609 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Comparison of DNA and mRNA vaccines against cancer.
Jahanafrooz Zohreh Z Baradaran Behzad B Mosafer Jafar J Hashemzaei Mahmoud M Rezaei Tayebeh T Mokhtarzadeh Ahad A Hamblin Michael R MR
Drug discovery today 20191213 3
Nucleic acid vaccines (NAVs) have recently been tested as a cancer therapy. DNA and mRNA vaccines deliver genetic information encoding tumor antigens (TAs) to the host, which then produces immune responses against cancer cells that express the TAs. Although NAVs are easy, safe, and simple to manufacture, they have not so far been considered viable alternatives to peptide vaccines. Choosing the right TAs, insufficient immunogenicity, and the immunosuppressive nature of cancer are some challenges ...[more]
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