Ontology highlight
ABSTRACT:
SUBMITTER: Dreydoppel M
PROVIDER: S-EPMC7080667 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Dreydoppel Matthias M Raum Heiner N HN Weininger Ulrich U
Journal of biomolecular NMR 20200203 2-3
Ring flips of phenylalanine and tyrosine are a hallmark of protein dynamics. They report on transient breathing motions of proteins. In addition, flip rates also depend on stabilizing interactions in the ground state, like aromatic stacking or cation-π interaction. So far, experimental studies of ring flips have almost exclusively been performed on aromatic rings without stabilizing interactions. Here we investigate ring flip dynamics of Phe and Tyr in the aromatic cluster in GB1. We found that ...[more]