Ontology highlight
ABSTRACT:
SUBMITTER: Yahya I
PROVIDER: S-EPMC7081242 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yahya Imadeldin I Böing Marion M Pu Qin Q Puchert Malte M Oedemis Veysel V Engele Jürgen J Brand-Saberi Beate B Morosan-Puopolo Gabriela G
Scientific reports 20200319 1
The present study shows that the CXCR4/SDF-1 axis regulates the migration of second branchial arch-derived muscles as well as non-somitic neck muscles. Cxcr4 is expressed by skeletal muscle progenitor cells in the second branchial arch (BA2). Muscles derived from the second branchial arch, but not from the first, fail to form in Cxcr4 mutants at embryonic days E13.5 and E14.5. Cxcr4 is also required for the development of non-somitic neck muscles. In Cxcr4 mutants, non-somitic neck muscle develo ...[more]