Tumor fitness, immune exhaustion and clinical outcomes: impact of immune checkpoint inhibitors.
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ABSTRACT:
SUBMITTER: Bubie A
PROVIDER: S-EPMC7081289 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Tumor fitness, immune exhaustion and clinical outcomes: impact of immune checkpoint inhibitors.
Bubie Adrian A Gonzalez-Kozlova Edgar E Akers Nicholas N Villanueva Augusto A Losic Bojan B
Scientific reports 20200319 1
Recently proposed tumor fitness measures, based on profiling neoepitopes for reactive viral epitope similarity, have been proposed to predict response to immune checkpoint inhibitors in melanoma and small-cell lung cancer. Here we applied these checkpoint based fitness measures to the matched checkpoint treatment naive Cancer Genome Atlas (TCGA) samples where cytolytic activity (CYT) imparts a known survival benefit. We observed no significant survival predictive power beyond that of overall pat ...[more]
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