Ontology highlight
ABSTRACT:
SUBMITTER: Allard D
PROVIDER: S-EPMC10259490 | biostudies-literature | 2023 Jun
REPOSITORIES: biostudies-literature
Allard David D Cousineau Isabelle I Ma Eric H EH Allard Bertrand B Bareche Yacine Y Fleury Hubert H Stagg John J
eLife 20230601
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials. Yet, the tumor cell-intrinsic impact of CD73 remain largely uncharacterized. Using metabolomics, we discovered that CD73 significantly enhances tumor cell mitochondrial respiration and aspartate biosynthesis. Importantly, rescuing aspartate biosynthesis was sufficient to resto ...[more]