Ontology highlight
ABSTRACT:
SUBMITTER: Oyen D
PROVIDER: S-EPMC7082059 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Oyen David D Torres Jonathan L JL Aoto Phillip C PC Flores-Garcia Yevel Y Binter Špela Š Pholcharee Tossapol T Carroll Sean S Reponen Sini S Wash Rachael R Liang Qi Q Lemiale Franck F Locke Emily E Bradley Allan A King C Richter CR Emerling Daniel D Kellam Paul P Zavala Fidel F Ward Andrew B AB Wilson Ian A IA
PLoS pathogens 20200309 3
Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies studied to date interact with the central NANP repeat region of PfCSP. However, it remains unclear what structural and functional characteristics correlate with better protection by one antibody over another. Binding to the junctional region between t ...[more]