Ontology highlight
ABSTRACT:
SUBMITTER: Mita P
PROVIDER: S-EPMC7082080 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Mita Paolo P Sun Xiaoji X Fenyö David D Kahler David J DJ Li Donghui D Agmon Neta N Wudzinska Aleksandra A Keegan Sarah S Bader Joel S JS Yun Chi C Boeke Jef D JD
Nature structural & molecular biology 20200210 2
Long interspersed element-1 (LINE-1, or L1) is the only autonomous retrotransposon that is active in human cells. Different host factors have been shown to influence L1 mobility; however, systematic analyses of these factors are limited. Here, we developed a high-throughput microscopy-based retrotransposition assay that identified the double-stranded break (DSB) repair and Fanconi anemia (FA) factors active in the S/G2 phase as potent inhibitors and regulators of L1 activity. In particular, BRCA ...[more]