Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes.

ABSTRACT: BACKGROUND:Decreased monocytic (m)HLA-DR expression is the most studied biomarker of sepsis-induced immunosuppression. To date, little is known about the relationship between sepsis characteristics, such as the site of infection, causative pathogen, or severity of disease, and mHLA-DR expression kinetics. METHODS:We evaluated mHLA-DR expression kinetics in 241 septic shock patients with different primary sites of infection and pathogens. Furthermore, we used unsupervised clustering analysis to identify mHLA-DR trajectories and evaluated their association with outcome parameters. RESULTS:No differences in mHLA-DR expression kinetics were found between groups of patients with different sites of infection (abdominal vs. respiratory, p?=?0.13; abdominal vs. urinary tract, p?=?0.53) and between pathogen categories (Gram-positive vs. Gram-negative, p?=?0.54; Gram-positive vs. negative cultures, p?=?0.84). The mHLA-DR expression kinetics differed between survivors and non-survivors (p?

SUBMITTER: Leijte GP 

PROVIDER: S-EPMC7082984 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature