Ontology highlight
ABSTRACT:
SUBMITTER: Tzakoniati F
PROVIDER: S-EPMC7083225 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cell chemical biology 20191112 3
Voltage-gated sodium (Nav) channels respond to changes in the membrane potential of excitable cells through the concerted action of four voltage-sensor domains (VSDs). Subtype Nav1.7 plays an important role in the propagation of signals in pain-sensing neurons and is a target for the clinical development of novel analgesics. Certain inhibitory cystine knot (ICK) peptides produced by venomous animals potently modulate Nav1.7; however, the molecular mechanisms underlying their selective binding an ...[more]