Ontology highlight
ABSTRACT:
SUBMITTER: Mathur S
PROVIDER: S-EPMC6963778 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cell chemical biology 20191216 1
Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate a host of (patho)physiological processes. The largest subtype are the RING E3s of which there are >600 members. RING E3s have adaptor-like activity that can be subject to diverse regulatory mechanisms and have become attractive drug targets. Activity-based probes (ABPs) for measurin ...[more]