Dataset Information

Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index.

ABSTRACT:

Aims

The definition of sarcopenia based on appendicular lean mass/height ⁽²⁾ (ALM/height ⁽²⁾ ) is often used, although it can underestimate the prevalence of sarcopenia in overweight/obese patients with heart failure. Therefore, new methods have been proposed to overcome this limitation. We aimed to evaluate the prevalence of sarcopenia by three methods and compare body composition in this population.

Methods and results

We enrolled 168 male patients with heart failure (left ventricular ejection fraction <40%). Sixty-six patients (39.3%) were identified with sarcopenia by at least one method. The lower 20th percentile defined as the cut-off point for sarcopenia was 7.03 kg/m² , -2.32 and 0.76 for Baumgartner's (20.8%), Newman's (21.4%), and Studenski's methods (21.4%), respectively. Patients with body mass index (BMI) <25 kg/m² were more likely to be identified by Baumgartner's than Studenski's method (P < 0.001). However, in patients with BMI ≥ 25 kg/m² , Studenski's and Newman's methods were more likely to detect sarcopenia than Baumgartner's method (both P < 0.005). Patients were further divided into three subgroups: (i) patients classified in all indexes (n = 8), (ii) patients classified in Baumgartner's (sarcopenic; n = 27), and (iii) patients classified in both Newman's and Studenski's methods (sarcopenic obesity; n = 31). Comparing body composition among groups, all sarcopenic groups presented lower total lean mass compared with non-sarcopenic patients, whereas sarcopenic obese patients had higher total lean mass than lean sarcopenic patients.

Conclusions

Our results demonstrate that the prevalence of sarcopenia in overweight/obese patients is similar to lean sarcopenic patients when other methods are considered. In patients with higher BMI, Studenski's method seems to be more feasible to detect sarcopenia.

SUBMITTER: Fonseca GWPD

PROVIDER: S-EPMC7083394 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index.

Fonseca G W P D GWPD Dos Santos Marcelo Rodrigues MR de Souza Francis Ribeiro FR Takayama Liliam L Rodrigues Pereira Rosa Maria RM Negrão Carlos Eduardo CE Alves Maria-Janieire de Nazaré Nunes MNN

ESC heart failure 20191226 1

<h4>Aims</h4>The definition of sarcopenia based on appendicular lean mass/height <sup>(2)</sup> (ALM/height <sup>(2)</sup> ) is often used, although it can underestimate the prevalence of sarcopenia in overweight/obese patients with heart failure. Therefore, new methods have been proposed to overcome this limitation. We aimed to evaluate the prevalence of sarcopenia by three methods and compare body composition in this population.<h4>Methods and results</h4>We enrolled 168 male patients with hea ...[more]

PMID: 31877587

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Dataset Information

Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index.

Aims

Methods and results

Conclusions

Publications

Discriminating sarcopenia in overweight/obese male patients with heart failure: the influence of body mass index.

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