Ontology highlight
ABSTRACT:
SUBMITTER: Busker S
PROVIDER: S-EPMC7083616 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Busker S S Qian W W Haraldsson M M Espinosa B B Johansson L L Attarha S S Kolosenko I I Liu J J Dagnell M M Grandér D D Arnér E S J ESJ Tamm K Pokrovskaja KP Page B D G BDG
Science advances 20200320 12
Because of its key role in cancer development and progression, STAT3 has become an attractive target for developing new cancer therapeutics. While several STAT3 inhibitors have progressed to advanced stages of development, their underlying biology and mechanisms of action are often more complex than would be expected from specific binding to STAT3. Here, we have identified and optimized a series of compounds that block STAT3-dependent luciferase expression with nanomolar potency. Unexpectedly, o ...[more]