Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6251801 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
Li Yang Y Zhang Yu Y Gan Qiwen Q Xu Meng M Ding Xiao X Tang Guihua G Liang Jingjing J Liu Kai K Liu Xuezhao X Wang Xin X Guo Lingli L Gao Zhiyang Z Hao Xiaojiang X Yang Chonglin C
Protein & cell 20180402 12
Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal abnormality using Caenorhabditis elegans (C. elegans) as a model system. A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D) were identified that caused lysosome enlargement in C. elegans macrophage-like cells. Intriguingly, t ...[more]