Ontology highlight
ABSTRACT:
SUBMITTER: von Roemeling CA
PROVIDER: S-EPMC7083893 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
von Roemeling Christina A CA Wang Yifan Y Qie Yaqing Y Yuan Hengfeng H Zhao Hai H Liu Xiujie X Yang Zhaogang Z Yang Mingming M Deng Weiye W Bruno Katelyn A KA Chan Charles K CK Lee Andrew S AS Rosenfeld Stephen S SS Yun Kyuson K Johnson Aaron J AJ Mitchell Duane A DA Jiang Wen W Kim Betty Y S BYS
Nature communications 20200320 1
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47. Here, we show that CD47 blockade alone is inefficient in stimulating glioma cell phagocytosis. However, combining CD47 blockade with temozolomide results in a significant pro-phagocytosis effect due to the latter's ability to induce endoplasmic reticulum stress response. Increased tumour cel ...[more]