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The Association of Aquaporin-1 Gene with Marathon Running Performance Level: a Confirmatory Study Conducted in Male Hispanic Marathon Runners.

ABSTRACT: BACKGROUND:Replication studies are essential for identifying credible associations between alleles and phenotypes. Validation of genotype-phenotype associations in the sports and exercise field is rare. An initial genetic association study suggested that rs1049305 (C > G) in the 3' untranslated region (3'UTR) of the aquaporin-1 (AQP1) gene was associated with marathon running (MR) performance level in Hispanic males. To validate this finding, we conducted a replication analysis in an independent case-control sample of Hispanic male marathon runners (n = 1430; cases n = 713 and controls n = 717). A meta-analysis was utilized to test the extent of the association between the initial results and the present report. It also provided to test the heterogeneity (variation) between the two studies. RESULTS:The replication study showed a statistically significant (p ? 0.05) association between rs1049305 (C > G) of the AQP1 gene and MR performance level. Association test results using a fixed effect model for the combined, original study and the present report, yielded an odds ratio = 1.28, 95% confidence interval = 1.13-1.45, p = 0.0001. The extent of the measures of heterogeneity was Tau-squared = 0, H statistic = 1, I2 statistic = 0, and Cochran's Q test (Q = 0.29; p value 0.59), indicated the variation between studies were due to chance and not to differences in heterogeneity between the two studies. Within the limitations of the present replication, contrast of two studies and its effects on meta-analysis, the findings were robust. CONCLUSION:This study successfully replicated the results of Martínez et al. (Med Sportiva 13:251-5, 2009). The meta-analysis provided further epidemiological credibility for the hypothesis of association between the DNA rs1049305 (C > G) variation in the 3'UTR of the AQP1 gene and MR running performance level in Hispanics male marathon runners. It is not precluded that a linked DNA structure in the surrounding molecular neighborhood could be of influence by been part of the overly complex phenotype of MR performance level.

SUBMITTER: Rivera MA

PROVIDER: S-EPMC7083975 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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The Association of Aquaporin-1 Gene with Marathon Running Performance Level: a Confirmatory Study Conducted in Male Hispanic Marathon Runners.

Rivera Miguel A MA Fahey Thomas D TD López-Taylor Juan R JR Martínez Juan L JL

Sports medicine - open 20200320 1

<h4>Background</h4>Replication studies are essential for identifying credible associations between alleles and phenotypes. Validation of genotype-phenotype associations in the sports and exercise field is rare. An initial genetic association study suggested that rs1049305 (C > G) in the 3' untranslated region (3'UTR) of the aquaporin-1 (AQP1) gene was associated with marathon running (MR) performance level in Hispanic males. To validate this finding, we conducted a replication analysis in an ind ...[more]

PMID: 32198675

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Project description:Simple Summary In the last decades, performance models have helped to comprehend the mechanisms involved in long-term physical performance. In addition, predictive models have aided in the evaluation and prescription of physical training. Here, we tested the hypothesis that physiological assessments under inclined conditions would better explain hilly running performance. We also checked the predictive role of running biomechanical, anthropometric, and neuromuscular factors. Velocity associated with maximal oxygen consumption was more predictive when assessed in inclined conditions (7%) than testing at level. Secondarily, ventilatory thresholds submaximal heart rate improved the performance models at hilly and level conditions. Spatiotemporal, strength, and anthropometric factors were not determinants of performance. Physiological assessments in inclined conditions predict 5-km running performance at hilly terrains in higher degree than evaluations at level in endurance runners. Abstract Incline and level running on treadmills have been extensively studied due to their different cardiorespiratory and biomechanical acute responses. However, there are no studies examining the performance determinants of outdoor running on hilly terrains. We aimed to investigate the influence of anthropometrics, muscle strength, and cardiorespiratory and gait spatiotemporal parameters during level (0%) and inclined (+7%) running on performance in level and hilly 5-km races. Twenty male recreational runners completed two 5-km outdoor running tests (0% vs. +7% and −7%), and two submaximal (10 km·h−1) and incremental treadmill tests at 0 and 7% slopes, after complete laboratory evaluations. The velocity at maximal oxygen consumption (VO2max) evaluated at 7% incline and level treadmill running were the best performance predictors under both hilly (R2 = 0.72; p < 0.05) and level (R2 = 0.85; p < 0.01) conditions, respectively. Inclusion of ventilatory and submaximal heart rate data improved the predictive models up to 100%. Conversely, none of the parameters evaluated in one condition contributed to the other condition. The spatiotemporal parameters and the runners’ strength levels were not associated to outdoor performances. These results indicate that the vVO2max evaluated at similar slopes in the lab can be used to predict 5-km running performances on both level and hilly terrains.

Project description:Psychological variables such as motivation, self-efficacy, and anxiety have been widely studied in marathon runners, usually within the framework of Bandura's theory of self-efficacy. It is also assumed a link between self-perceived fitness and physiological performance parameters such as speed at ventilatory thresholds and running economy. The purpose of this paper is to describe longitudinal trends of self-perceptions and examine their link to physiological performance parameters over time. Sixteen healthy recreational marathoners (8 males and 8 females), aged M = 37.6 (SD = 3.9) who were about to participate in a major marathon agreed to participate. After 3 months of regular training and competition in shorter distances, all participants trained during a 16-week macrocycle under the supervision of the same coaching staff. At 4-week intervals, the participants responded five times the Podium questionnaire, measuring self-perceived psychological state relative to the upcoming race, and performed five exercise performance parameters tests. Linear mixed-effects models were used to analyze the trends and associations. In general, Podium questionnaire scores were within the standard range, with the lowest values at the beginning and the highest values closer to race day. Although only perceived fitness (p < 0.001, Cohen's f 2 = 1.19) and somatic anxiety (p < 0.001, f 2 = 0.32) showed large effect sizes for the whole longitudinal period, other partial increases were found between time points. All physiological performance parameters presented significant improvements over time (Aerobic Threshold speed, p < 0.001, f 2 = 1.04; Anaerobic Threshold speed, p < 0.001, f 2 = 0.498; Running Economy in VO2, p < 0.001, f 2 = 0.349; Running Economy in energy, p = 0.024, f 2 = 0.197). The analysis of changes between consecutive time points revealed that improving perceived physical condition predicted improving self-efficacy (p < 0.001, f 2 = 1.33), and improvements in motivation were predicted by improvements in either self-efficacy (p < 0.001, f 2 = 0.36) or perceived physical condition (p = 0.003, f 2 = 0.17). Improvements in perceived fitness, self-efficacy and motivation were associated with small effect-size improvements (decreases) in anxiety. None of the physiological performance parameters was shown to predict changes in psychological variables, although their general trends over time correlated. The results have practical implications for sport psychologists and running coaches, supporting the need for integrated working.

Project description:BackgroundLong-distance running is a popular form of cardiovascular exercise with many well-described health benefits, from improving heart health to the management of obesity, diabetes, and mental illness. The impact of long-distance running on joint health in recreational runners, however, remains inconclusive.HypothesisThe prevalence of osteoarthritis in runners is not associated with an athlete's running-related history, including the number of marathons completed, cumulative years of running, average weekly mileage, and average running pace.Study designProspective cohort study.Level of evidenceLevel 3.MethodsA survey was distributed to all participants registered for the 2019 or 2021 Chicago marathon (n = 37,917). Surveys collected runner demographics and assessed for hip/knee pain, osteoarthritis, family history, surgical history, and running-related history. Running history included the number of marathons run, number of years running, average running pace, and average weekly mileage. The overall prevalence of osteoarthritis was identified, and a multivariable logistic regression model was used to identify variables associated with the presence of hip and/or knee osteoarthritis.ResultsSurveys were completed by 3804 participants (response rate of 10.0%). The mean age was 43.9 years (range, 18-83 years) and participants had completed on average 9.5 marathons (median, 5 marathons; range, 1-664 marathons). The prevalence of hip and/or knee arthritis was 7.3%. A history of hip/knee injuries or surgery, advancing age, family history, and body mass index (BMI) were risk factors for arthritis. Cumulative number of years running, number of marathons completed, weekly mileage, and mean running pace were not significant predictors for arthritis. The majority (94.2%) of runners planned to run another marathon, despite 24.2% of all participants being told by a physician to do otherwise.ConclusionFrom this largest surveyed group of marathon runners, the most significant risk factors for developing hip or knee arthritis were age, BMI, previous injury or surgery, and family history. There was no identified association between cumulative running history and the risk for arthritis.

Project description:Introduction:Marathon, as a long-distance aerobic exercise, has become a fashionable or popular sport. However, little is known about the holistic metabolic changes occurring within the serum metabolome of athletes after the completion of a marathon. Objectives:The goal of current study was to have an in-depth understanding of the impact of marathon on human metabolomics as well as the relationships among a variety of metabolites. Methods:The 20 studied subjects were all adult males who participated in a marathon. The serum samples of these participants were collected before and after the marathon and the biochemical metabolites in the serum were identified by an untargeted two-dimensional gas chromatography time-of-flight mass spectrometry. Results:All participants completed the marathon within 3?h. Compared to those before exercise, serum urea and creatine kinase, as well as cortisol, elevated significantly (p?<?0.05), whereas testosterone decreased significantly (p?<?0.01). Metabolomic analysis showed that, compared to those before the competition, metabolites pyruvic acid, glyceric acid, malic acid, cis-aconitic acid, galacturonic acid, methyl fumaric acid, maltotriose, and others increased significantly after the competition (p?<?0.05), but glucosamine and O-succinyl-L-homoserine decreased significantly (p?<?0.05). Amino acid indexes, such as alanine, L-tyrosine and phenylalanine, increased significantly after exercise compared with those before exercise (p?<?0.05), whereas serine, valine and asparagine decreased significantly (p?<?0.05). Lipid metabolism indexes, glycerol, glyceric acid, octanoic acid, and quinic acid increased significantly (p?<?0.05). Theophylline, xanthine and other indicators of caffeine metabolism increased significantly (p?<?0.05). Furthermore, marathon performance, fat percentage, VO2max, and hemoglobin were correlated with the serum metabonomic indicators, so were serum testosterone and cortisol. Conclusion:These results illustrate that the metabolism of glucose and lipid of the athletes was enhanced following the marathon match. In addition, the metabolism of glucosamine was decreased and the metabolism of caffeine was increased. Our data provide new insights for marathon performance and nutritional status.

Dataset Information

The Association of Aquaporin-1 Gene with Marathon Running Performance Level: a Confirmatory Study Conducted in Male Hispanic Marathon Runners.

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The Association of Aquaporin-1 Gene with Marathon Running Performance Level: a Confirmatory Study Conducted in Male Hispanic Marathon Runners.

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