Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
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ABSTRACT:
SUBMITTER: Piro MC
PROVIDER: S-EPMC7084269 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
Piro Maria Cristina MC Ventura Alessandra A Smirnov Artem A Saggini Andrea A Lena Anna Maria AM Mauriello Alessandro A Bianchi Luca L Melino Gerry G Candi Eleonora E
International journal of molecular sciences 20200225 5
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT ...[more]
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