Ontology highlight
ABSTRACT:
SUBMITTER: Grosse GM
PROVIDER: S-EPMC7084464 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Grosse Gerrit M GM Schwedhelm Edzard E Worthmann Hans H Choe Chi-Un CU
International journal of molecular sciences 20200305 5
The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and symmetric dimethylarginine (SDMA), are regarded as markers of endothelial dysfunction and have been implicated in vascular disorders. While there is a variety of studies consolidating ADMA as biomarker of cerebrovascular risk, morbidity and mortality, SDMA is currently emerging as an interesting metabolite with disti ...[more]