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Aquaporin-4 and Cerebrovascular Diseases.


ABSTRACT: Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema. Considering brain edema is an important pathophysiological change after stoke, AQP4 is destined to have close relation with cerebrovascular diseases. However, this relation is not limited to brain edema due to other biological effects elicited by AQP4. Till now, multiple studies have investigated roles of AQP4 in cerebrovascular diseases. This review focuses on expression of AQP4 and the effects of AQP4 on brain edema and neural cells injuries in cerebrovascular diseases including cerebral ischemia, intracerebral hemorrhage and subarachnoid hemorrhage. In the current review, we pay more attention to the studies of recent years directly from cerebrovascular diseases animal models or patients, especially those using AQP4 gene knockout mice. This review also elucidates the potential of AQP4as an excellent therapeutic target.

SUBMITTER: Chu H 

PROVIDER: S-EPMC5000647 | biostudies-other | 2016 Aug

REPOSITORIES: biostudies-other

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Aquaporin-4 and Cerebrovascular Diseases.

Chu Heling H   Huang Chuyi C   Ding Hongyan H   Dong Jing J   Gao Zidan Z   Yang Xiaobo X   Tang Yuping Y   Dong Qiang Q  

International journal of molecular sciences 20160811 8


Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema. Considering brain edema is an important pathophysiological change after stoke, AQP4 is destined to have close relation with cerebrovascular diseases. However, this relation is not limited to brain edema due to other biological effects elicited by  ...[more]

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