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The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism.

ABSTRACT: Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast cancer patients, and its effectiveness as a target for comprehensive therapy of breast cancer; (2) the biological effects and molecular mechanisms of WT1 in the development and progression of breast cancer, including proliferation, apoptosis, invasion, and metastasis of breast cancer cells.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC7085227 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism.

Zhang Ye Y Yan Wen-Ting WT Yang Ze-Yu ZY Li Yan-Ling YL Tan Xuan-Ni XN Jiang Jun J Zhang Yi Y Qi Xiao-Wei XW

International journal of biological sciences 20200224 8

Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with high tissue- and cell-specificity. This article reviews the relationship between WT1 and breast cancer from two aspects: (1) clinical application of WT1, including the relationship between expression of WT1 and prognosis of breast canc ...[more]

PMID: 32210734

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