Amyloid duration is associated with preclinical cognitive decline and tau PET.
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ABSTRACT:
SUBMITTER: Koscik RL
PROVIDER: S-EPMC7085284 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Amyloid duration is associated with preclinical cognitive decline and tau PET.
Koscik Rebecca L RL Betthauser Tobey J TJ Jonaitis Erin M EM Allison Samantha L SL Clark Lindsay R LR Hermann Bruce P BP Cody Karly A KA Engle Jonathan W JW Barnhart Todd E TE Stone Charles K CK Chin Nathaniel A NA Carlsson Cynthia M CM Asthana Sanjay S Christian Bradley T BT Johnson Sterling C SC
Alzheimer's & dementia (Amsterdam, Netherlands) 20200213 1
<h4>Introduction</h4>This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age-heterogeneous amyloid trajectory groups, estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in relation to cognitive decline and tau burden.<h4>Methods</h4>Cognitively unimpaired participants (<i>n</i> = 257) underwent one to four amyloid PET scans (Pittsburgh Compound B, PiB). Group-based trajectory modeling was ap ...[more]
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