Dataset Information

Associations of long-term exposure to ambient PM₁ with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

ABSTRACT:

Background

The epidemiological evidence on relationships between long-term exposure to particulate matter and hypertension and blood pressure has been inconclusive. Limited evidence was available for particulate matter with an aerodynamic diameter???1??m (PM₁) in rural areas of developing countries.

Objective

This study aimed to investigate the associations between long-term exposure to PM₁ and hypertension and blood pressure among rural Chinese population.

Methods

This study included 39,259 participants who had completed the baseline survey from Henan Rural Cohort. Participants' exposure to PM₁ was assessed by a satellite-based spatiotemporal model. The binary logistic regression model was used to examine the association between long-term PM₁ exposure and hypertension, and multivariable linear regression model was used to investigate the associations between long-term PM₁ exposure and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure (PP). Moreover, we examined potential effect modifications by demographic, lifestyle and diet factors.

Results

The mean concentration of PM₁ for all participants during the 3-year before baseline survey was 59.98??g/m³. Each 1??g/m³ increase in PM₁ concentration was significantly associated with an increase of 4.3% [Odds ratio(OR)?=?1.043, 95% confidence interval(CI): 1.033, 1.053] in odds for hypertension, an increase of 0.401?mm?Hg (95% CI, 0.335, 0.467), 0.328?mm?Hg (95% CI, 0.288, 0.369), 0.353?mm?Hg (95% CI, 0.307, 0.399) and 0.073?mm?Hg (95% CI, 0.030, 0.116) in SBP, DBP, MAP and PP, respectively. Further stratified analyses showed that the effect of PM₁ on hypertension and blood pressure could be modified by sex, lifestyle and diet.

Conclusions

This study suggests that long-term exposure to ambient PM₁ increases the risk of hypertension and is associated with elevations in blood pressure in rural Chinese adults, especially in male and those with unhealthy habits.

SUBMITTER: Li N

PROVIDER: S-EPMC7086153 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of long-term exposure to ambient PM<sub>1</sub> with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

Li Na N Chen Gongbo G Liu Feifei F Mao Shuyuan S Liu Yisi Y Hou Yitan Y Lu Yuanan Y Liu Suyang S Wang Chongjian C Xiang Hao H Guo Yuming Y Li Shanshan S

Environment international 20190503

<h4>Background</h4>The epidemiological evidence on relationships between long-term exposure to particulate matter and hypertension and blood pressure has been inconclusive. Limited evidence was available for particulate matter with an aerodynamic diameter ≤ 1 μm (PM<sub>1</sub>) in rural areas of developing countries.<h4>Objective</h4>This study aimed to investigate the associations between long-term exposure to PM<sub>1</sub> and hypertension and blood pressure among rural Chinese population.<h ...[more]

PMID: 31035115

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Project description:BackgroundThe concentration-response relationship between mortality and long-term exposure to fine particulate matter (PM2.5) has not been fully elucidated, especially at high levels of PM2.5 concentrations.ObjectiveWe aimed to evaluate chronic effects of ambient PM2.5 exposure on deaths among Chinese adults in high-exposure settings.MethodsParticipants of the Prediction for Atherosclerotic cardiovascular disease Risk in China (China-PAR) project were included from four prospective cohorts among Chinese adults aged ≥18 years old. The overall follow-up rate of the four cohorts was 93.4% until the recent follow-up survey that ended in 2015. The average of satellite-based PM2.5 concentrations during 2000-2015 at 1-km spatial resolution was assigned to each participant according to individual residence addresses. Based on the pooled analysis of individual data from the four cohorts, a Cox proportional hazards model was used to estimate the hazard ratio (HR) and corresponding 95% confidence intervals (95% CIs) for the association of PM2.5 exposure with mortality after multivariate adjustment.ResultsA total of 116,821 participants were eligible in the final analysis. During a mean of 7.7 years of follow-up, 6,395 non-accidental deaths and 2,507 cardio-metabolic deaths occurred. The mean of PM2.5 concentration was 64.9 μg/m3 ranging from 31.2 μg/m3 to 97.0 μg/m3. For each 10 μg/m3 increment in PM2.5, the HR was 1.11 (95% CI: 1.08-1.14) for non-accidental mortality and 1.22 (95% CI: 1.16-1.27) for cardio-metabolic mortality. In addition, a weak exponential curve for the concentration-response association between mortality and PM2.5 was observed among Chinese adults.ConclusionsOur study provided important evidence of the long-term effects of PM2.5 exposure on deaths among Chinese adults. The findings expand our knowledge on concentration-response relationship in high-exposure environments, which is essential to address the urgent challenge of reducing the disease burden attributable to PM2.5 exposure in rapidly industrializing countries such as China.

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Dataset Information

Associations of long-term exposure to ambient PM₁ with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

Background

Objective

Methods

Results

Conclusions

Publications

Associations of long-term exposure to ambient PM<sub>1</sub> with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

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OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Associations of long-term exposure to ambient PM1 with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

Background

Objective

Methods

Results

Conclusions

Publications

Associations of long-term exposure to ambient PM<sub>1</sub> with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Associations of long-term exposure to ambient PM₁ with hypertension and blood pressure in rural Chinese population: The Henan rural cohort study.