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Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists.

ABSTRACT: The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.

SUBMITTER: Spell SR 

PROVIDER: S-EPMC7086404 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists.

Spell Sarah R SR   Mangrum John B JB   Peterson Erica J EJ   Fabris Daniele D   Ptak Roger R   Farrell Nicholas P NP  

Chemical communications (Cambridge, England) 20161201 1

The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN<sub>4</sub> compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist. ...[more]

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