Ontology highlight
ABSTRACT:
SUBMITTER: Spell SR
PROVIDER: S-EPMC7086404 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20161201 1
The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN<sub>4</sub> compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist. ...[more]