Ontology highlight
ABSTRACT:
SUBMITTER: Donovan C
PROVIDER: S-EPMC7088894 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Donovan Chantal C Hansbro Philip M PM
ACS pharmacology & translational science 20191220 1
IL-33 has been deorphanized as a member of the IL-1 family and has key roles as an alarmin and cytokine with potent capacity to drive type 2 inflammation. This has led to a plethora of studies surrounding its role in chronic diseases with a type 2 inflammatory component. Here, we review the roles of IL-33 in two chronic respiratory diseases, asthma and chronic obstructive pulmonary disease (COPD). We discuss the hallmark and paradigm-shifting studies that have contributed to our understanding of ...[more]