Ontology highlight
ABSTRACT:
SUBMITTER: Toth K
PROVIDER: S-EPMC7088988 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Toth Krisztian K Nagi Karim K Slosky Lauren M LM Rochelle Lauren L Ray Caroline C Kaur Suneet S Shenoy Sudha K SK Caron Marc G MG Barak Larry S LS
ACS pharmacology & translational science 20190603 4
G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement depend on multiple receptor determinants. Using ghrelin receptor GHR1a, we demonstrate by bioluminescence resonance energy transfer and fluorescence microscopy a critical role for its second intracellular loop 2 (ICL2) domain in stabilizing β-arrestin/GHSR1a core interactions ...[more]