Ontology highlight
ABSTRACT:
SUBMITTER: Obermajer N
PROVIDER: S-EPMC7089406 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Obermajer Nataša N Sattin Sara S Colombo Cinzia C Bruno Michela M Svajger Urban U Anderluh Marko M Bernardi Anna A
Molecular diversity 20101114 2
In this article, we describe the design, synthesis and activity evaluation of glycomimetic DC-SIGN antagonists, that use a mannose residue to anchor to the protein carbohydrate recognition domain (CRD). The molecules were designed from the structure of the known pseudo-mannobioside antagonist 1, by including additional hydrophobic groups, which were expected to engage lipophilic areas of DC-SIGN CRD. The results demonstrate that the synthesized compounds potently inhibit DC-SIGN-mediated adhesio ...[more]