Ontology highlight
ABSTRACT:
SUBMITTER: Graziadei A
PROVIDER: S-EPMC7089733 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Graziadei Andrea A Gabel Frank F Kirkpatrick John J Carlomagno Teresa T
eLife 20200323
2'-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. Despite the conservation of the methylation sites, the abundance of site-specific modifications shows variability across species and tissues, suggesting that rRNA methylation may provide a means of controlling gene expression. As all Box C/D RNPs are thought to adopt a similar structure, it remains unclear how the methylation efficiency is regulated. Here, we prov ...[more]