Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC7090062 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chen Wei W Li Zhouqi Z Liu Hao H Jiang Sujing S Wang Guannan G Sun Lifeng L Li Jun J Wang Xiaochen X Yu Shaojun S Huang Jianjin J Dong Ying Y
Cell death & disease 20200323 3
Gastrointestinal stromal tumors (GISTs), the most widespread type of sarcoma, contain driver gene mutations predominantly of receptor tyrosine kinase and platelet-derived growth factor receptor alpha. However, the inevitable development of resistance to imatinib (IM) cannot be fully attributed to secondary driver gene mutations. In this study, we investigated the role of microRNA-30a in sensitization of GIST cells to IM in vivo and in vitro. Higher levels of miR-30a were detected in GIST-T1 cell ...[more]