Ontology highlight
ABSTRACT:
SUBMITTER: Auzmendi J
PROVIDER: S-EPMC7090129 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Auzmendi Jerónimo J Palestro Pablo P Blachman Agustín A Gavernet Luciana L Merelli Amalia A Talevi Alan A Calabrese Graciela Cristina GC Ramos Alberto Javier AJ Lazarowski Alberto A
Frontiers in behavioral neuroscience 20200317
Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of patients develop refractory epilepsy (RE) characterized by a multidrug-resistant (MDR) phenotype. The "transporters hypothesis" indicates that the mechanism of this MDR phenotype is the overexpression of ABC transporters such as P-glycoprotein (P-gp) in the neurovascular unit cells, limiting access of the AEDs to the brain. Recent clinical trials and basic studies have shown encouraging results for the use of ca ...[more]