Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W.
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ABSTRACT:
SUBMITTER: Gong R
PROVIDER: S-EPMC7092852 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
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Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W.
Gong Rui R Peng Xiaoxue X Kang Shuli S Feng Huixing H Huang Jianying J Zhang Wentao W Lin Donghai D Tien Po P Xiao Gengfu G
Biochemical and biophysical research communications 20050601 4
Syncytin is a captive retroviral envelope protein, possibly involved in the formation of the placental syncytiotrophoblast layer generated by trophoblast cell fusion at the maternal-fetal interface. We found that syncytin and type I viral envelope proteins shared similar structural profiling, especially in the regions of N- and C-terminal heptad repeats (NHR and CHR). We expressed the predicted regions of NHR (41aa) and CHR (34aa) in syncytin as a native single chain (named 2-helix protein) to c ...[more]
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