Ontology highlight
ABSTRACT:
SUBMITTER: Van Rompay KKA
PROVIDER: S-EPMC7093037 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Van Rompay Koen K A KKA Keesler Rebekah I RI Ardeshir Amir A Watanabe Jennifer J Usachenko Jodie J Singapuri Anil A Cruzen Christina C Bliss-Moreau Eliza E Murphy Ashley M AM Yee JoAnn L JL Webster Helen H Dennis Maria M Singh Tulika T Heimsath Holly H Lemos Danilo D Stuart Jackson J Morabito Kaitlyn M KM Foreman Bryant M BM Burgomaster Katherine E KE Noe Amy T AT Dowd Kimberly A KA Ball Erin E Woolard Kevin K Presicce Pietro P Kallapur Suhas G SG Permar Sallie R SR Foulds Kathryn E KE Coffey Lark L LL Pierson Theodore C TC Graham Barney S BS
Science translational medicine 20191201 523
Zika virus (ZIKV) infection of pregnant women is associated with congenital Zika syndrome (CZS) and no vaccine is available, although several are being tested in clinical trials. We tested the efficacy of ZIKV DNA vaccine VRC5283 in a rhesus macaque model of congenital ZIKV infection. Most animal vaccine experiments have a set pathogen exposure several weeks or months after vaccination. In the real world, people encounter pathogens years or decades after vaccination, or may be repeatedly exposed ...[more]