Ontology highlight
ABSTRACT:
SUBMITTER: Lowe R
PROVIDER: S-EPMC7093186 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lowe Robert R Danson Amy F AF Rakyan Vardhman K VK Yildizoglu Selin S Saldmann Frédéric F Viltard Melanie M Friedlander Gérard G Faulkes Chris G CG
Aging 20200303 5
The naked mole-rat, <i>Heterocephalus glaber</i> (NMR), the longest-lived rodent, is of significance and interest in the study of biomarkers for ageing. Recent breakthroughs in this field have revealed 'epigenetic clocks' that are based on the temporal accumulation of DNA methylation at specific genomic sites. Here, we validate the hypothesis of an epigenetic clock in NMRs based on changes in methylation of targeted CpG sites. We initially analysed 51 CpGs in NMR livers spanning an age range of ...[more]