Ontology highlight
ABSTRACT:
SUBMITTER: Chung HJ
PROVIDER: S-EPMC7093540 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Chung Hea-Jong HJ Jamal Mohammad Abu Hena Mostofa MAHM Hong Seong-Tshool ST
Scientific reports 20200324 1
Although the malfunction of HtrA2/Omi leads to Parkinson's disease (PD), the underlying mechanism has remained unknown. Here, we showed that HtrA2/Omi specifically removed oligomeric α-Syn but not monomeric α-Syn to protect oligomeric α-Syn-induced neurodegeneration. Experiments using mnd2 mice indicated that HtrA2/Omi degraded oligomeric α-Syn specifically without affecting monomers. Transgenic Drosophila melanogaster experiments of the co-expression α-Syn and HtrA2/Omi and expression of genes ...[more]