Ontology highlight
ABSTRACT:
SUBMITTER: Lee CY
PROVIDER: S-EPMC7093554 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lee Chung-Young CY An Se-Hee SH Choi Jun-Gu JG Lee Youn-Jeong YJ Kim Jae-Hong JH Kwon Hyuk-Joon HJ
Scientific reports 20200324 1
The PB2 gene is one of the key determinants for the mammalian adaptation of avian influenza A viruses (IAVs). Although mammalian pathogenicity-related mutations (MPMs) in PB2 genes were identified in different genetic backgrounds of avian IAVs, the relative effects of single or multiple mutations on viral fitness could not be directly compared. Furthermore, their mutational steps during mammalian adaptation had been unclear. In this study, we collectively compared the effects of individual and c ...[more]