Ontology highlight
ABSTRACT:
SUBMITTER: Guerrero CLH
PROVIDER: S-EPMC7094015 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Guerrero Carmina Louise Hugo CLH Yamashita Yoshiko Y Miyara Megumi M Imaizumi Naoki N Kato Megumi M Sakihama Shugo S Hayashi Masaki M Miyagi Takashi T Karimata Kaori K Uchihara Junnosuke J Ohshiro Kazuiku K Todoroki Junpei J Nakachi Sawako S Morishima Satoko S Karube Kennosuke K Tanaka Yuetsu Y Masuzaki Hiroaki H Fukushima Takuya T
Blood advances 20200301 6
Adult T-cell leukemia/lymphoma (ATL) is a human T-cell leukemia virus type 1 (HTLV-1)-associated T-cell malignancy with generally poor prognosis. Although only ∼5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. In this study, we analyzed blood plasma profiles of asymptomatic HTLV-1 carriers (ACs); untreated ATL patients, including acute, lymphoma, smoldering, and chronic types; and ATL patients in remission. Through SOMAscan, expression ...[more]