Ontology highlight
ABSTRACT:
SUBMITTER: Lin SM
PROVIDER: S-EPMC7094172 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lin Shan-Meng SM Lin Shih-Chao SC Hsu Jia-Ning JN Chang Chung-Ke CK Chien Ching-Ming CM Wang Yong-Sheng YS Wu Hung-Yi HY Jeng U-Ser US Kehn-Hall Kylene K Hou Ming-Hon MH
Journal of medicinal chemistry 20200311 6
Structure-based stabilization of protein-protein interactions (PPIs) is a promising strategy for drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Here, we identified a non-native interaction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted ...[more]