Ontology highlight
ABSTRACT:
SUBMITTER: Kim BK
PROVIDER: S-EPMC7094222 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kim Bo-Kyoung BK Cho Joong-Heui JH Jeong Pyeonghwa P Lee Youngjin Y Lim Jia Jia JJ Park Kyoung Ryoung KR Eom Soo Hyun SH Kim Yong-Chul YC
FEBS letters 20150525 15
Coxsackievirus B3 is the main cause of human viral myocarditis and cardiomyopathy. Virally encoded Coxsackievirus 3C protease (3C(pro)) plays an essential role in viral proliferation. Here, benserazide was discovered as a novel inhibitor from a drug library screen targeting Coxsackievirus 3C(pro) using a FRET-based enzyme assay. Benserazide, whose chemical structure has no electrophilic functional groups, was characterized as a non-competitive inhibitor by enzyme kinetic studies. A molecular doc ...[more]