Dataset Information

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.

ABSTRACT: BACKGROUND:Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. METHODS:We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. RESULTS:In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. CONCLUSIONS:The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

SUBMITTER: Kong XZ

PROVIDER: S-EPMC7094802 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.

Kong Xiang-Zhen XZ Boedhoe Premika S W PSW Abe Yoshinari Y Alonso Pino P Ameis Stephanie H SH Arnold Paul D PD Assogna Francesca F Baker Justin T JT Batistuzzo Marcelo C MC Benedetti Francesco F Beucke Jan C JC Bollettini Irene I Bose Anushree A Brem Silvia S Brennan Brian P BP Buitelaar Jan J Calvo Rosa R Cheng Yuqi Y Cho Kang Ik K KIK Dallaspezia Sara S Denys Damiaan D Ely Benjamin A BA Feusner Jamie J Fitzgerald Kate D KD Fouche Jean-Paul JP Fridgeirsson Egill A EA Glahn David C DC Gruner Patricia P Gürsel Deniz A DA Hauser Tobias U TU Hirano Yoshiyuki Y Hoexter Marcelo Q MQ Hu Hao H Huyser Chaim C James Anthony A Jaspers-Fayer Fern F Kathmann Norbert N Kaufmann Christian C Koch Kathrin K Kuno Masaru M Kvale Gerd G Kwon Jun Soo JS Lazaro Luisa L Liu Yanni Y Lochner Christine C Marques Paulo P Marsh Rachel R Martínez-Zalacaín Ignacio I Mataix-Cols David D Medland Sarah E SE Menchón José M JM Minuzzi Luciano L Moreira Pedro S PS Morer Astrid A Morgado Pedro P Nakagawa Akiko A Nakamae Takashi T Nakao Tomohiro T Narayanaswamy Janardhanan C JC Nurmi Erika L EL O'Neill Joseph J Pariente Jose C JC Perriello Chris C Piacentini John J Piras Fabrizio F Piras Federica F Pittenger Christopher C Reddy Y C Janardhan YCJ Rus-Oswald Oana Georgiana OG Sakai Yuki Y Sato Joao R JR Schmaal Lianne L Simpson H Blair HB Soreni Noam N Soriano-Mas Carles C Spalletta Gianfranco G Stern Emily R ER Stevens Michael C MC Stewart S Evelyn SE Szeszko Philip R PR Tolin David F DF Tsuchiyagaito Aki A van Rooij Daan D van Wingen Guido A GA Venkatasubramanian Ganesan G Wang Zhen Z Yun Je-Yeon JY Thompson Paul M PM Stein Dan J DJ van den Heuvel Odile A OA Francks Clyde C

Biological psychiatry 20190430 12

<h4>Background</h4>Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD.<h4>Methods</h4>We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) ...[more]

PMID: 31178097

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Project description:Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K?=?0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P?<?0.0001), lower modularity (P?<?0.0001), and lower small-worldness (P?=?0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions.

Dataset Information

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.

Publications

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.

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