Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.
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SUBMITTER: Bruin WB
PROVIDER: S-EPMC7598942 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.
Bruin Willem B WB Taylor Luke L Thomas Rajat M RM Shock Jonathan P JP Zhutovsky Paul P Abe Yoshinari Y Alonso Pino P Ameis Stephanie H SH Anticevic Alan A Arnold Paul D PD Assogna Francesca F Benedetti Francesco F Beucke Jan C JC Boedhoe Premika S W PSW Bollettini Irene I Bose Anushree A Brem Silvia S Brennan Brian P BP Buitelaar Jan K JK Calvo Rosa R Cheng Yuqi Y Cho Kang Ik K KIK Dallaspezia Sara S Denys Damiaan D Ely Benjamin A BA Feusner Jamie D JD Fitzgerald Kate D KD Fouche Jean-Paul JP Fridgeirsson Egill A EA Gruner Patricia P Gürsel Deniz A DA Hauser Tobias U TU Hirano Yoshiyuki Y Hoexter Marcelo Q MQ Hu Hao H Huyser Chaim C Ivanov Iliyan I James Anthony A Jaspers-Fayer Fern F Kathmann Norbert N Kaufmann Christian C Koch Kathrin K Kuno Masaru M Kvale Gerd G Kwon Jun Soo JS Liu Yanni Y Lochner Christine C Lázaro Luisa L Marques Paulo P Marsh Rachel R Martínez-Zalacaín Ignacio I Mataix-Cols David D Menchón José M JM Minuzzi Luciano L Moreira Pedro S PS Morer Astrid A Morgado Pedro P Nakagawa Akiko A Nakamae Takashi T Nakao Tomohiro T Narayanaswamy Janardhanan C JC Nurmi Erika L EL O'Neill Joseph J Pariente Jose C JC Perriello Chris C Piacentini John J Piras Fabrizio F Piras Federica F Reddy Y C Janardhan YCJ Rus-Oswald Oana G OG Sakai Yuki Y Sato João R JR Schmaal Lianne L Shimizu Eiji E Simpson H Blair HB Soreni Noam N Soriano-Mas Carles C Spalletta Gianfranco G Stern Emily R ER Stevens Michael C MC Stewart S Evelyn SE Szeszko Philip R PR Tolin David F DF Venkatasubramanian Ganesan G Wang Zhen Z Yun Je-Yeon JY van Rooij Daan D Thompson Paul M PM van den Heuvel Odile A OA Stein Dan J DJ van Wingen Guido A GA
Translational psychiatry 20201008 1
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the compl ...[more]
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Project description:The notion that some special brain regions may be involved in the pathogenesis of obsessive-compulsive disorder (OCD) dates back to the beginning of the twentieth century. Structural neuroimaging studies in the past 2 decades have revealed important findings that facilitate understanding of OCD pathogenesis. Current knowledge based on functional and structural neuroimaging investigations largely emphasizes abnormalities in fronto-striatal-thalamic-cortical and orbitofronto-striato-thalamic circuits in the pathophysiology of OCD. However, these neuroimaging studies did not focus on refractory OCD. The present review mainly focused on structural neuroimaging performed in OCD, which had been ignored previously, and highlighted current evidence supporting that orbito-frontal cortex and thalamus are key brain regions, and that the hippocampus-amygdala complex is associated with refractoriness to the available treatment strategies. However, to fully reveal the neuroanatomy of refractoriness, longitudinal studies with larger samples are required.
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