Ontology highlight
ABSTRACT:
SUBMITTER: Guan Y
PROVIDER: S-EPMC7096161 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Guan Yongjuan Y Leu N Adrian NA Ma Jun J Chmátal Lukáš L Ruthel Gordon G Bloom Jordana C JC Lampson Michael A MA Schimenti John C JC Luo Mengcheng M Wang P Jeremy PJ
Science advances 20200325 13
The meiotic prophase I to metaphase I (PI/MI) transition requires chromosome desynapsis and metaphase competence acquisition. However, control of these major meiotic events is poorly understood. Here, we identify an essential role for SKP1, a core subunit of the SKP1-Cullin-F-box (SCF) ubiquitin E3 ligase, in the PI/MI transition. SKP1 localizes to synapsed chromosome axes and evicts HORMAD proteins from these regions in meiotic spermatocytes. SKP1-deficient spermatocytes display premature desyn ...[more]