Ontology highlight
ABSTRACT:
SUBMITTER: Pausch TM
PROVIDER: S-EPMC7096431 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Pausch Thomas M TM Aue Elisa E Wirsik Naita M NM Freire Valls Aida A Shen Ying Y Radhakrishnan Praveen P Hackert Thilo T Schneider Martin M Schmidt Thomas T
Scientific reports 20200325 1
The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a key contributor to its lethality. This stromal microenvironment is populated by cancer-associated fibroblasts (CAFs) that interact with cancer cells to drive progression and chemo-resistance. Research has focused on CAFs in the primary tumour but not in metastases, calling into question the role of analogous metastasis-associated fibroblasts (MAFs). We infer a role of MAFs in murine hepatic metastases followin ...[more]