Ontology highlight
ABSTRACT:
SUBMITTER: Okada K
PROVIDER: S-EPMC7096515 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Okada Keita K Mori Daisuke D Makii Yuma Y Nakamoto Hideki H Murahashi Yasutaka Y Yano Fumiko F Chang Song Ho SH Taniguchi Yuki Y Kobayashi Hiroshi H Semba Hiroaki H Takeda Norihiko N Piao Wen W Hanaoka Kenjiro K Nagano Tetsuo T Tanaka Sakae S Saito Taku T
Scientific reports 20200325 1
HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to be revealed. We examined HIF-1α protein expression and the hypoxic condition during mouse osteoarthritis (OA) development using state of the art hypoxic probes and found that its expression decreased as OA progressed, coinciding with the change in hypoxic conditions in articular cartilage. Gain- and loss ...[more]