Serum D-lactate concentrations in dogs with parvoviral enteritis.

ABSTRACT:

Background

Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D-lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid-base status in these dogs.

Hypothesis

Serum D-lactate concentration will be increased in CPV dogs compared to healthy controls and correlate with markers of disease severity and acid-base status.

Animals

Dogs with CPV undergoing treatment (n = 40) and healthy control dogs (n = 9).

Methods

Prospective observational study. Dogs with CPV had a baseline and daily CBC, venous blood gas with serum electrolyte concentrations, composite clinical severity score, and serum D-lactate concentration performed. A single serum D-lactate measurement was obtained from healthy control dogs.

Results

The CPV dogs had a higher D-lactate concentration (mean?±?SD) of 469?±?173??M compared to controls, 306?±?45??M (P?Conclusions and clinical importanceSerum D-lactate concentrations are higher in dogs with CPV compared to healthy controls but do not appear to be clinically relevant. No relationship identified between serum D-lactate concentrations and markers of CPV disease severity, acid-base status, or outcome.

SUBMITTER: Venn EC 

PROVIDER: S-EPMC7096611 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature