Ontology highlight
ABSTRACT:
SUBMITTER: Nieva JL
PROVIDER: S-EPMC7097105 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Nature reviews. Microbiology 20120702 8
Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to their involvement in several diverse steps of the viral life cycle. Thus, these viral proteins, which include influenza A virus matrix protein 2 (M2), HIV-1 viral protein U (Vpu) and ...[more]