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Architecture of the SARS coronavirus prefusion spike.

ABSTRACT: The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core.

SUBMITTER: Beniac DR

PROVIDER: S-EPMC7097490 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

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Architecture of the SARS coronavirus prefusion spike.

Beniac Daniel R DR Andonov Anton A Grudeski Elsie E Booth Tim F TF

Nature structural & molecular biology 20060716 8

The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core. ...[more]

PMID: 16845391

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