Ontology highlight
ABSTRACT:
SUBMITTER: Jose Maria Carazo
PROVIDER: EMPIAR-10516 | biostudies-other |
REPOSITORIES: biostudies-other
Melero Roberto R Sorzano Carlos Oscar S COS Foster Brent B Vilas José-Luis JL Martínez Marta M Marabini Roberto R Ramírez-Aportela Erney E Sanchez-Garcia Ruben R Herreros David D Del Caño Laura L Losana Patricia P Fonseca-Reyna Yunior C YC Conesa Pablo P Wrapp Daniel D Chacon Pablo P McLellan Jason S JS Tagare Hemant D HD Carazo Jose-Maria JM
IUCrJ 20200929 Pt 6
Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-terminal domain, and subdomains 1 and 2 around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations. It is shown that in this data set there are not well defined, ...[more]