Dataset Information
Cryo electron microscopy of SARS-CoV-2 spike in prefusion state
Ontology highlight
ABSTRACT:
SUBMITTER: Jose Maria Carazo
PROVIDER: EMPIAR-10516 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures.
IUCrJ 20200929 Pt 6
Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-terminal domain, and subdomains 1 and 2 around the previously characterized 1-RBD-up state, which have been modeled as elastic deformations. It is shown that in this data set there are not well defined, ...[more]